• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The present invention relates to the development and method of obtaining a hydrogel-type formulation, composed of cationic polymers, preferably chitosan, crosslinked with the trisodium salt of 6-phosphogluconic acid as a system for the modified release of active substances or drugs for administration via topical, transdermal or other routes, destined to local or systemic treatments. This system can be applied lyophilized on wounds or rehydrated on healthy skin to which it adheres forming a transparent film that protects it. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2671184A1
    申请号:ES201631463
    申请日:2016-11-16
    公开日:2018-06-05
    发明作者:María Teresa MARTÍNEZ MARTÍNEZ；María Isabel GONZÁLEZ ALVAREZ；Marta GONZÁLEZ ÁLVAREZ；María DEL VAL BERMEJO SANZ；Guillermo RODRÍQUEZ BERNA；Avelino Corma Canós；Virginia MERINO SANJUÁN
    申请人:Consejo Superior de Investigaciones Cientificas CSIC；Universidad Politecnica de Valencia；Universidad Miguel Hernandez de Elche；Universitat de Valencia；
    IPC主号:
    专利说明:

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    In a particular embodiment, the polymer is chitosan; preferably in concentrations of 1 to 3% w / v. Chitosan can be used in a wide range of molecular weights, preferably 50 to 375 kDa, and with different degrees of deacetylation. The reaction between 6-PG-Na + and chitosan results in a hydrogel-like formulation that is capable of harboring active substances inside and releasing them after application. The structure of said compounds is as follows:
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    Trisodium salt of 6-phosphogluconic acid (6-PG-Na +) Chitosan
    The hydrogel preparation is carried out with a solution of the polymer in
    15 acidic medium to which a solution of 6-PG-Na + in water is added. This mixture is stirred in the vortex for 1 to 3 minutes, forming the hydrogel and freeze-drying. The molar ratio of this formulation is 1: X moles of chitosan repeating units in relation to the moles of 6-PG-Na +, where X = 0.5-5.
    20 After obtaining the lyophilized product, it can be rehydrated with water. The result is a viscous formulation that can be spread on the skin. After a few minutes, the formulation dries, sticking to the skin, mucous membranes or cavities and begins to release the compound trapped inside.
    Next, for a better understanding of the invention, the following example is provided, without limiting the invention.
    In a particular embodiment, the active substance is Piroxicam between 0.1% and 10% by weight of the formulation. This drug is useful in anti-inflammatory treatment. In a standard preparation, a certain amount of a stock solution of Piroxicam dissolved in acetone was added to a glass vial that was allowed to evaporate (0.5% by weight of the formulation). Next, chitosan (PM = 190-310 kDa) dissolved at 2% (15 mg dry weight) was incorporated on the Piroxicam, and the sample was homogenized by vortexing and sonication on ultrasound. Finally, different volumes of a stock solution of 6-PG-Na + in water (100 mg / ml), whose molar amounts were added
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    权利要求:
    Claims (1)
    [1]
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    类似技术:
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    Zagórska-Dziok et al.2020|Hydrogel-based active substance release systems for cosmetology and dermatology application: A review
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    Stahl et al.2014|The effects of chemical and physical penetration enhancers on the percutaneous permeation of lidocaine through equine skin
    ES2215924T3|2004-10-16|DERMIC APPLICATION SYSTEM FOR AMINOLEVULINIC ACID.
    WO2012102210A1|2012-08-02|Gel composition and use thereof
    Magalhães et al.2017|PAMAM dendrimer hydrogel film—Biocompatible material to an efficient dermal delivery of drugs
    ES2750818T3|2020-03-27|Hypericin formulation for photodynamic therapy
    Peng et al.2021|Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections
    Parhi et al.2015|Formulation optimization of PVA/HPMC cryogel of Diltiazem HCl using 3-level factorial design and evaluation for ex vivo permeation
    Soujanya et al.2014|Formulation and in vitro & in vivo evaluation of transdermal patches of lornoxicam using natural permeation enhancers
    Mobed-Miremadi et al.2013|Polystyrene microsphere and 5-fluorouracil release from custom-designed wound dressing films
    BR102019010734A2|2020-12-01|PROCESS OF OBTAINING POLYMERIC MEMBRANE COATED WITH NANOPARTICLE FOR DRUG RELEASE FOR SKIN HEALING AND PRODUCT OBTAINED
    US20190365797A1|2019-12-05|Systems and Methods for Delivery of Nitric Oxide
    同族专利:
    公开号 | 公开日
    ES2671184B2|2019-02-04|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    WO2016091778A1|2014-12-12|2016-06-16|Kiomed Pharma|Chitosan hydrogel microbead|
    法律状态:
    2019-02-04| FG2A| Definitive protection|Ref document number: 2671184 Country of ref document: ES Kind code of ref document: B2 Effective date: 20190204 |
    优先权:
    申请号 | 申请日 | 专利标题
    ES201631463A|ES2671184B2|2016-11-16|2016-11-16|FORMULATION FOR MODIFIED RELEASE OF ACTIVE SUBSTANCES OR DRUGS, USE AND PROCEDURE OF OBTAINING|ES201631463A| ES2671184B2|2016-11-16|2016-11-16|FORMULATION FOR MODIFIED RELEASE OF ACTIVE SUBSTANCES OR DRUGS, USE AND PROCEDURE OF OBTAINING|
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